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Background Chronic insomnia is highly prevalent in the world. Its effects on the sympatho-adrenal system could potentially worsen hypertension and cause metabolic abnormalities. However, there is lack of evidence of the association between insomnia and adverse renal outcomes. Methods We examined associations of chronic insomnia (defined as the presence of ICD9 codes 307.42, 307.49 and 780.52 and long-term use of insomnia medications) with all-cause mortality and renal outcomes, (ESRD, incidence of eGFR 60 ml/min/1.73m 2. Drake trey songz beef. Associations were examined in Cox proportional hazards models and logistic regressions. Besides crude models (model 1), adjustments were made for demographics and baseline estimated GFR (model 2), BMI and blood pressure (Model 3), comorbidities, antihypertensive drugs, and social-economic status (Model 4).

Results 41,928 patients (4.4%) had chronic insomnia. Over a 6.1-year median follow-up period, 23.1% of patients died [mortality rate: 39.4/1000 patient-years (PY)], 0.2% reached ESRD (event rate: 0.2/1000PY), 6.6% of them progressed to eGFR.

Housing Research Leasehold: A Life Sentence? Thousands of homeowners are stuck in properties they cannot afford to continue living in and cannot sell, because they bought them as leasehold. In most cases, buyers were unaware of what being a leaseholder would mean, and some didn’t realise they were only buying the lease until it was too late. Elliptic curve cryptography is far from being supported as a standard option in most cryptographic deployments. Despite three NIST curves having been standardized, at the 128-bit security level or higher, the smallest curve size, secp256r1, is by far the most commonly used. Many servers seem to prefer the curves de ned over smaller elds.